Obesity continues to be a growing problem in the U.S. – a problem that can lead to a host of health issues, including an enhanced risk of developing colorectal cancer. One factor propelling the rise in obesity rates is the use of high-fructose corn syrup (HFCS). New findings show that a specific enzyme in tumors (ketohexokinase) converts HFCS into fructose-1-phosphate, a compound that works to modify tumor cell metabolism and increases tumor growth, even in those who aren’t obese. This may explain why an increased intake of HFCS over the past few decades has corresponded with elevated rates of colorectal cancer in the U.S.
Goncalves MD. High-fructose corn syrup enhances intestinal tumor growth in mice. Science. 22Mar2019: Vol.363, Issue 6433, pp. 1345-1349. DOI 10.1126/science.aat8515.